LAB metabolites: Food product test results
Koei Science Lab has spent years of research studying the great potential of lactic acid bacteria metabolites to promote human health. The list of tests seen here is testament to that effort.
The experiments were performed in vitro (i.e. using test tubes) and on mice, meaning that the results do not offer direct proof of effectiveness in humans.
You can see the PDF version. Please click the left PDF button.Anti-diabetic effect
You can see the PDF version. Please click the left PDF button.Anti-allergic effect
You can see the PDF version. Please click the left PDF button.Triglyceride-lowering effect
You can see the PDF version. Please click the left PDF button.Anti-tumor effect
LAB metabolites: Food product safety testing
LAB metabolites have been shown to be safe when taken as a food product, according to the following tests.
Safety of LAB metabolites: Evaluation of nutritional and physiological properties using rats / September 2005
LAB metabolites in liquid concentrate and extract form were processed into powder and mixed with purified, powdered feed for rats. This food was given to healthy male rats (approx. 3 ml/rat/day, approx. 6 ml/rat/day). Weight gain, feed efficiency, organ weights, blood sugar and various serum biochemical parameters were monitored, and LAB metabolites were not found to affect any of these. Accordingly, it was determined that, nutritionally and physiologically, LAB metabolites are highly safe for normal growing rats.(Tested at Josai International University, Faculty of Pharmaceutical Sciences)
90-day repeated dose toxicity in rats of a mixture of LAB metabolites concentrated extract and powdered solid / June 2004
The toxicity of a mixture of LAB metabolites concentrated extract and powdered solids was tested on rats. The subjects were divided into three groups: a low dose group (10 ml/kg/day), a high dose group (20 ml/kg/day), and a control group (purified water: 20 ml/kg/day). The doses were administered via the oral route once daily for 90 days. No changes were observed in either the male or female rats that were thought to be caused by the LAB metabolites. Accordingly, it was concluded that with the mixture used, even a dose of 20 ml/kg/day (the maximum for this test) would have no adverse effects.(Tested at Drug Safety Testing Center Co., Ltd.)
Clinical test of LAB metabolites extract on healthy individuals / June 1998
The subjects, healthy males aged 20 to 40, were divided into four groups. One group was given a placebo while the others were given LAB metabolites extract (low dose: 3.5 ml; medium dose: 7.0 ml; high dose: 10.55 ml) twice daily. We had them report any subjective symptoms, and studied their blood, urinary tract systems, circulatory systems and electrocardiograms. The test conditions were controlled by having the subjects stay in a shared facility and eat the same meals during the test period. Among those in the groups given LAB metabolites, some subjects showed increased appetites and more consistent bowel movements, and there was nothing in the other data to indicate that the LAB metabolites had had any adverse effects.(Tested at Beijing Chest Hospital in China)